1. La stimolazione ormonale per la fecondazione in vitro non aumenta il rischio di sviluppare un cancro mammario

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Ovarian Stimulation for In Vitro Fertilization and Long-term Risk of Breast Cancer                                                                                 van den Belt-Dusebout AW, Spaan M, Lambalk CB, Kortman M, et Al 

Abstract                                                                                                                                                                                    Previous studies of breast cancer risk after in vitro fertilization (IVF) treatment were inconclusive due to limited follow-up.            Exposures: information on ovarian stimulation for IVF, other fertility treatments, and potential confounders was collected from medical records and through mailed questionnaires.                                                                                                                                    Main outcomes and measures: incidence of invasive and in situ breast cancers in women who underwent fertility treatments was obtained through linkage with the Netherlands Cancer Registry (1989-2013). Breast cancer risk in the IVF group was compared with risks in the general population (standardized incidence ratios [SIRs]) and the non-IVF group (hazard ratios [HRs]).                                             Results: among 25,108 women (mean age at baseline, 32.8 years; mean number of IVF cycles, 3.6), 839 cases of invasive breast cancer and 109 cases of in situ breast cancer occurred after a median follow-up of 21.1 years. Breast cancer risk in IVF-treated women was not significantly different from that in the general population (SIR, 1.01 [95% CI, 0.93-1.09]) and from the risk in the non-IVF group (HR, 1.01 [95% CI, 0.86-1.19]). The cumulative incidences of breast cancer at age 55 were 3.0% for the IVF group and 2.9% for the non-IVF group (P = .85). The SIR did not increase with longer time since treatment (≥20 years) in the IVF group (0.92 [95% CI, 0.73-1.15]) or in the non-IVF group (1.03 [95% CI, 0.82-1.29]). Risk was significantly lower for those who underwent 7 or more IVF cycles (HR, 0.55 [95% CI, 0.39-0.77]) vs 1 to 2 IVF cycles and after poor response to the first IVF cycle (HR, 0.77 [95% CI, 0.61-0.96] for <4 vs ≥4 collected oocytes).                                                                                                                                    Conclusion: of recent Australian cancer survivors, 14 % report continued smoking.                                                                            Impication for cancer survivors: smoking following a cancer diagnosis is associated with increased risk of mortality and further morbidity. There is a need to target cessation efforts towards survivors who are younger, without a partner and with a low level of education.

 JAMA. 2016 Jul 19;316(3):300-12. doi: 10.1001/jama.2016.9389.

2. Difficoltà comunicative e perdita di interesse sessuale in pazienti giovani

Sexual and Romantic Relationships: Experiences of Adolescent and Young Adult Cancer Survivors                                           Robertson EG, Sansom-Daly UM, Wakefield CE, Ellis SJ, McGill BC, Doolan EL, Cohn RJ

Abstract                                                                                                                                                                                    This study examined the quality and satisfaction of sexual/romantic relationships of adolescents/young adults (AYAs) who recently completed cancer treatment. AYAs between 16 and 26 years old (62.5% female) and less than 24 months post-treatment were interviewed using the Psychosocial Adjustment to Illness Scale (PAIS) interview. Of 43 participants, 16 (37.2%) were in a relationship at time of the interview; eight (50%) reported minor relationship/sexual difficulties. AYAs identified emotional support with their partner as positive aspects of their relationships, and described relational conflict associated with communication difficulties and loss of sexual interest. Better understanding the factors that enable healthy relationships warrants further exploration. Vestibulum ante ipsum primis in faucibus orci luctus et ultrices posuere cubilia Curae. Mauris egestas at nibh nec finibus. Donec ac fringilla turpis. Mauris egestas at nibh nec finibus. In sit amet felis malesuada, feugiat purus eget, varius mi. Vivamus a ante congue, porta nunc nec, hendrerit turpis.

 

J Adolesc Young Adult Oncol. 2016 Feb 17. [Epub ahead of print]

3. Donne operate di cancro al seno subiscono un disagio in termini di carriera lavorativa anche a distaznza di 10 anni dalla diagnosi di cancro e dalle cure

Employment and social benefits up to 10 years after breast cancer diagnosis: a population-based study                                      Paalman CH, van Leeuwen FE, Aaronson NK, De Boer AG, Van de Poll-Franse L, Oldenburg HS, Schaapveld M

Abstract                                                                                                                                                                                    Background: little is known about employment outcomes after breast cancer (BC) beyond the first years after treatment.                    Methods: employment outcomes were compared with a general population comparison group (N=91 593) up to 10 years after BC for 26 120 patients, diagnosed before age 55 between 2000-2005, with income and social benefits data from Statistics Netherlands. Treatment effects were studied in 14 916 patients, with information on BC recurrences and new cancer events.                                     Results: BC survivors experienced higher risk of losing paid employment (Hazard Ratio (HR): 1.6, 95% Confidence Interval (95% CI) 1.4-1.8) or any work-related event up to 5-7 years (HR 1.5, 95% CI 1.3-1.6) and of receiving disability benefits up to 10 years after diagnosis (HR 2.0, 95% CI 1.6-2.5), with higher risks for younger patients. Axillary lymph node dissection increased risk of disability benefits (HR 1.5, 95% CI 1.4-1.7) or losing paid employment (HR 1.3, 95% CI 1.2-1.5) during the first 5 years of follow-up. Risk of disability benefits was increased among patients receiving mastectomy and radiotherapy (HR 1.2; 95% CI 1.1-1.3) and after chemotherapy (HR 1.7; 95% CI 1.5-1.9) during the first 5 years after diagnosis.                                                                               Conclusions: BC treatment at least partly explains the increased risk of adverse employment outcomes up to 10 years after BC.

Br J Cancer. 2016 Jan 12;114(1):81-7. doi: 10.1038/bjc.2015.431                                                                                                 PMID: 26757424 [PubMed - in process]

 

4. Una quota parte non idifferente di pazienti affetti da cancro continua a fumare a distanza di 6 mesi dalla diagnosi

Prevalence and factors related to smoking and smoking cessation 6 months following a cancer diagnosis: a population-based study Bryant J, Boyes AW, Hall A, Girgis A, D'Este C, Sitas F

Abstract                                                                                                                                                                                    Purpose: limited research has examined smoking amongst recent cancer survivors or the relative contribution of factors on smoking behaviour. This study aimed to describe amongst recent Australian cancer survivors (i) prevalence of smoking by cancer type, (ii) characteristics associated with continued smoking following diagnosis, (iii) intention to quit among those who continue to smoke and (iv) characteristics associated with quitting following diagnosis.                                                                                                       Methods: cross-sectional data were analysed from 1299 cancer survivors diagnosed with their first primary cancer recruited from two Australian cancer registries in Australia between 2006 and 2008.                                                                                                      Results: of participants, 8.6 % reported current smoking. Participants who were younger and single or widowed reported higher odds of current smoking. Participants who had a certificate/diploma or tertiary education reported lower odds of smoking. Among current smokers, 53 % intended to quit in the future. Lung cancer survivors reported more than four times the odds of quitting smoking since diagnosis compared to other cancer types.                                                                                                                                      Conclusions: of recent Australian cancer survivors, 14 % report continued smoking.                                                                       Implication for cancer survivors: smoking following a cancer diagnosis is associated with increased risk of mortality and further morbidity. There is a need to target cessation efforts towards survivors who are younger, without a partner and with a low level of education.

Br J Cancer. 2016 Jan 12;114(1):81-7. doi: 10.1038/bjc.2015.431.                                                                                                J Cancer Surviv. 2016 Jan 13. [Epub ahead of print]